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Key MDCG Guidance Documents for IVDR Compliance

An overview of the most important Medical Device Coordination Group guidance documents relevant to IVDR implementation and how to apply them in practice.

IVDR.net Editorial Team
22 October 2025
7 min read

MDCG Guidance for IVDR

The Medical Device Coordination Group (MDCG) has published numerous guidance documents to support the implementation of IVDR. These documents, while not legally binding, represent the agreed interpretation of regulatory requirements by EU Member State competent authorities and the European Commission.

Essential MDCG Guidance Documents

MDCG 2020-16 Rev.2 — Guidance on Classification of IVD Medical Devices This guidance provides practical examples and flowcharts for applying the IVDR classification rules. It is an essential reference for manufacturers navigating the new risk-based classification system.

MDCG 2022-10 — Q&A on the IVDR Transitional Provisions This document addresses frequently asked questions about the transitional provisions, including the conditions under which devices can continue to be placed on the market under IVDD certificates during the transition period.

MDCG 2022-2 Rev.1 — Guidance on General Safety and Performance Requirements Provides interpretation of the GSPR requirements in Annex I of the IVDR, helping manufacturers understand how to demonstrate compliance with these fundamental requirements.

MDCG 2022-12 — Guidance on Performance Evaluation of IVD Medical Devices This comprehensive guidance covers the planning, conduct, and reporting of performance evaluations under IVDR Annex XIII. It addresses scientific validity, analytical performance, and clinical performance assessment.

How to Use MDCG Guidance

While MDCG guidance documents are not legally binding, they represent the regulatory community's agreed interpretation of IVDR requirements. Manufacturers should:

  1. Monitor the European Commission's website for new and updated guidance
  2. Incorporate relevant guidance into their compliance strategies
  3. Document how they have addressed applicable guidance in their technical documentation
  4. Discuss any deviations from guidance with their Notified Body

Staying Current

The MDCG continues to publish new guidance documents as implementation questions arise. Manufacturers should establish a process for monitoring and reviewing new guidance to ensure their compliance approach remains aligned with regulatory expectations.

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